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Extensively Studied

BPC-157

BPC-157 is a synthetic pentadecapeptide (15 amino acids) derived from a protective protein found in human gastric juice.

Also known as: Body Protection Compound-157, Pentadecapeptide

Typical Dose 250-500mcg
Storage Refrigerate reconstituted; store lyophilized powder away from light
How Often 1-2x daily

Overview

BPC-157 is a synthetic pentadecapeptide (15 amino acids) derived from a protective protein found in human gastric juice. It's known for its remarkable healing properties and is extensively researched for tissue repair, inflammation reduction, and gastrointestinal protection. Not FDA approved and prohibited by WADA (added 2022) under S0: Non-Approved Substances - no TUE available for athletes.

Key Benefits

  • Ulcer Protection
  • Intestinal Repair
  • Mucosal Healing

Accelerated healing of tendons, ligaments, muscles, bones, and localized tissue repair. Superior bioavailability for targeted healing with anti-inflammatory effects.

Mechanism of Action

Injectable BPC-157 provides direct tissue targeting and higher local concentrations. Promotes angiogenesis (formation of new blood vessels), enhances collagen synthesis, modulates growth factor expression, and provides localized protection against tissue damage.

Pharmacokinetics

Peak plasma concentration: 1 hr. Elimination half-life: 4 hrs. Largely cleared by: ~20 hrs.

Research Protocols Injectable

GoalDoseFrequencyRoute
Tendon/Joint healing250-500mcg1-2x dailySubcutaneous
Serious injury500-1000mcg2x dailySubcutaneous
General healing250-500mcg1-2x dailySubcutaneous
Maintenance250mcg1x dailySubcutaneous

Research protocols from published literature — not dosing recommendations.

Peptide Interactions

  • TB-500 — Synergistic: Complementary healing mechanisms, often used together
  • GHRP-6 — Compatible: No known negative interactions
  • Ipamorelin — Synergistic: BPC-157 increases GH receptor expression, amplifying Ipamorelin's growth hormone benefits
  • CJC-1295 — Synergistic: BPC-157 upregulates GH receptors, enhancing CJC-1295 effectiveness for tissue repair
  • Melanotan II — Compatible: No known interactions - different mechanisms of action and receptor targets
  • AOD-9604 — Compatible: Safe combination - BPC-157 promotes tissue repair via growth factors, AOD-9604 targets fat metabolism via beta-3 adrenergic receptors. No pathway overlap. Often combined in regenerative protocols.
  • L-Carnitine — Compatible: No known interactions - different mechanisms with BPC-157 supporting tissue repair and L-Carnitine supporting energy metabolism via fatty acid transport.

Peptide Instructions Injectable

Supplies:

  • Bacteriostatic water (BAC water)
  • Insulin syringes (0.5-1mL)
  • Alcohol swabs
  • Peptide vial
  • Sterile work surface

How to Reconstitute Injectable

  1. 1Clean work area and hands thoroughly
  2. 2Calculate required BAC water volume using calculator below
  3. 3Draw BAC water into syringe
  4. 4Inject slowly down vial side (not directly onto powder)
  5. 5Gently swirl until dissolved (never shake)
  6. 6Store reconstituted vial in refrigerator (2–6°C), use within 28 days
  7. 7For long-term storage of unreconstituted lyophilized powder: freezer at -20°C or colder, sealed and protected from light — stable for multiple years

What to Expect Injectable

Week 1-2: Reduced inflammation and pain at injection site. Week 2-4: Improved healing rate and tissue repair. Week 4-8: Maximum localized healing benefits. Side effects: Mild injection site redness or irritation. Most effective for: Tendon, ligament, muscle injuries.

Side Effects & Safety

May cause mild injection site reactions. Consult doctor if on blood thinners due to angiogenesis effects. Not recommended during pregnancy or breastfeeding. WADA prohibited (S0: Non-Approved Substances) - not for competitive athletes.

May cause mild injection site reactions. Consult doctor if on blood thinners due to angiogenesis effects. Not recommended during pregnancy or breastfeeding. WADA prohibited (S0: Non-Approved Substances) - not for competitive athletes.

Community Insights

BPC-157 should be stored at Fridge 2-6°C, use within 28 days.

Molecular Information

Molecular Weight 1,419.53 Da
Length 15
Type Pentadecapeptide
Sequence Gly-Lys-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val

References

  1. Multifunctionality and Possible Medical Application of the BPC 157 Peptide—Literature and Patent Review Jóźwiak, M., Bauer, M., Kamysz, W., Kleczkowska, P. · Pharmaceuticals 2025
  2. Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157 He, L., Feng, D., Guo, H., et al. · Frontiers in Pharmacology 2022
  3. Pentadecapeptide BPC 157 and the central nervous system Vukojevic, J., Milavić, M., Perović, D., et al. · Neural Regeneration Research 2022
  4. Stable Gastric Pentadecapeptide BPC 157 and Wound Healing Seiwerth, S., Milavic, M., Vukojevic, J., et al. · Frontiers in Pharmacology 2021
  5. Stable Gastric Pentadecapeptide BPC 157, Robert's Stomach Cytoprotection Sikiric, P., Hahm, K.B., Blagaic, A.B., et al. · Gut and Liver 2020
  6. Preclinical safety evaluation of body protective compound-157, a potential drug for treating various wounds Xu, C., Sun, L., Ren, F., et al. · Regulatory Toxicology and Pharmacology 2020
  7. Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats Perovic, D., Kolenc, D., Bilic, V., et al. · Journal of Orthopaedic Surgery and Research 2019
  8. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation Hsieh, M.J., Liu, H.T., Wang, C.N., et al. · Journal of Molecular Medicine 2017
  9. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration Chang, C.H., Tsai, W.C., Lin, M.S., Hsu, Y.H., Pang, J.H. · Journal of Applied Physiology 2011
  10. Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract Sikiric, P., Seiwerth, S., Rucman, R., et al. · Current Pharmaceutical Design 2011
  11. Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157 Staresinic, M., Petrovic, I., Novinscak, T., et al. · Journal of Orthopaedic Research 2006
  12. Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth Staresinic, M., Sebecic, B., Patrlj, L., et al. · Journal of Orthopaedic Research 2003

Research reference only. Not medical advice.