Sermorelin

Sermorelin acetate is a 29-amino acid synthetic analog of human growth hormone-releasing hormone (GHRH) originally FDA-approved in 1997 for pediatric growth hormone deficiency. Despite discontinuation in 2008 for manufacturing reasons, it maintains excellent safety profile and stimulates natural growth hormone production while preserving physiological pulsatile patterns.

• Lean Body Mass Enhancement
• IGF-1 Mediated Growth
• Athletic Performance Support

FDA-proven efficacy, 6% bioavailability, maintains natural GH pulses, preserves pituitary function

Subcutaneous injection provides optimal bioavailability with rapid onset (5-20 minutes) and physiological pulsatile GH stimulation

Peak plasma concentration: 10 min. Elimination half-life: 12 min. Largely cleared by: ~1 hr.

Research protocols from published literature — not dosing recommendations.

• Ipamorelin — Synergistic: Excellent combination producing 3-5 fold increases in GH release. GHRH and GHRP work through different pathways with proven synergistic effects in clinical studies.
• CJC-1295 — Synergistic: Highly effective combination - CJC-1295 provides sustained 6-8 day release while sermorelin offers immediate pulsatile effects. Commonly dosed together in clinical protocols.
• GHRP-2 — Synergistic: Combined GHRH+GHRP-2 produces 54-fold GH increases compared to 20-fold with GHRH alone. Well-documented synergistic mechanism.
• Octreotide — Avoid Combination: Somatostatin analogs directly block GH release by activating inhibitory somatostatin receptors, completely negating sermorelin therapeutic effects.
• Lanreotide — Avoid Combination: Another somatostatin analog that inhibits GH release through direct receptor antagonism, making combination with sermorelin counterproductive.
• Prednisone — Use Caution: High-dose glucocorticoids suppress pituitary GH release and reduce GHRH receptor sensitivity. Requires dose adjustments and IGF-1 monitoring.
• Insulin — Monitor Combination: GH antagonizes insulin action through IGF-1-mediated effects. Monitor blood glucose and consider insulin dose adjustments during sermorelin therapy.
• Thyroid Hormones — Compatible: Essential combination as untreated hypothyroidism prevents sermorelin response. 6.5% of patients develop hypothyroidism requiring hormone replacement.

Supplies:

• Sermorelin acetate lyophilized powder (2-5mg vial)
• Bacteriostatic water for injection (3mL typically)
• Insulin syringes (28-30 gauge)
• Alcohol swabs for sterilization
• Sterile technique supplies

1. 1Allow sermorelin vial to reach room temperature before reconstitution
2. 2Clean vial top with alcohol swab and allow to dry
3. 3Inject 3mL bacteriostatic water slowly against vial wall (not directly onto powder)
4. 4Gently swirl vial in circular motion - do not shake vigorously to avoid foaming
5. 5Allow to sit for 2-3 minutes until powder completely dissolves into clear solution
6. 6Store reconstituted solution at 2-8°C and use within 10-30 days depending on formulation
7. 7Inject subcutaneously at 45-degree angle rotating between lower abdomen, thigh, and upper arm sites

Week 1-2: IGF-1 levels begin to rise, possible improved sleep quality and recovery. Week 2-4: Enhanced body composition changes begin, increased energy and well-being. Week 4-8: Visible muscle tone improvements, fat reduction, skin quality enhancement. Week 8-12: Sustained body composition improvements, optimal IGF-1 elevation achieved. Month 3-6: Maximum benefits including muscle growth, fat loss, and anti-aging effects.

Monitor thyroid function - 6.5% develop hypothyroidism requiring hormone replacement. Check IGF-1 levels monthly initially, then every 3-6 months long-term. Injection site reactions occur in 16.7% of patients but are generally mild. Contraindicated in active malignancy, pituitary tumors, and pregnancy.

Monitor thyroid function - 6.5% develop hypothyroidism requiring hormone replacement. Check IGF-1 levels monthly initially, then every 3-6 months long-term. Injection site reactions occur in 16.7% of patients but are generally mild. Contraindicated in active malignancy, pituitary tumors, and pregnancy.

Sermorelin should be stored at Lyophilized: 2-8°C up to 3 years; Reconstituted: 2-8°C for 10-30 days.