TB-500
TB-500 is a synthetic 7-amino acid fragment (Ac-LKKTETQ) corresponding to the active actin-binding region (positions 17-23) of thymosin beta-4.
Also known as: Ac-LKKTETQ, Synthetic Fragment (17-23) of Thymosin Beta-4
Overview
TB-500 is a synthetic 7-amino acid fragment (Ac-LKKTETQ) corresponding to the active actin-binding region (positions 17-23) of thymosin beta-4. Originally developed for veterinary use in horses, this fragment retains tissue repair and anti-inflammatory properties while being more stable than the full peptide. Banned by WADA for its performance-enhancing effects
Key Benefits
- Muscle Regeneration
- Tendon & Ligament Healing
- Wound Healing
Superior systemic tissue repair, accelerated healing of muscles, tendons, ligaments, and organs. Enhanced cell migration and angiogenesis for comprehensive regenerative effects.
Mechanism of Action
Injectable TB-500 provides systemic distribution for whole-body tissue repair. Acts as the principal actin-sequestering protein, regulating cell migration, promoting angiogenesis, reducing inflammation, and activating stem cell differentiation for accelerated healing.
Pharmacokinetics
Peak plasma concentration: 30 min. Elimination half-life: 2.5 hrs. Largely cleared by: ~12.5 hrs.
Research Protocols Injectable
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| General tissue repair | 2-3mg | 2x weekly | Subcutaneous |
| Serious injury recovery | 4-5mg | 3x weekly | Subcutaneous |
| Athletic enhancement | 2-3mg | 2x weekly | Subcutaneous |
| Chronic conditions | 3-4mg | 2-3x weekly | Subcutaneous |
| Maintenance | 2mg | 1-2x weekly | Subcutaneous |
| Post-surgical recovery | 3-5mg | 3x weekly | Subcutaneous |
Research protocols from published literature — not dosing recommendations.
Peptide Interactions
- BPC-157 — Synergistic: Complementary healing mechanisms with enhanced tissue repair when used together
- Ipamorelin — Compatible: TB-500 may enhance tissue sensitivity to growth hormone effects
- CJC-1295 — Synergistic: TB-500 tissue repair combined with GH-releasing effects for comprehensive recovery
- IGF-1 — Synergistic: Enhanced muscle and tissue regeneration through complementary growth pathways
- GHRP-6 — Compatible: No known negative interactions, potential for enhanced recovery
- Melanotan II — Compatible: No interaction expected - TB-500 promotes tissue repair via actin regulation, Melanotan II acts on melanocortin receptors. Completely different receptor families with no pathway overlap.
Peptide Instructions Injectable
Supplies:
- Bacteriostatic water (BAC water)
- Insulin syringes (1mL recommended)
- Alcohol swabs
- TB-500 vial (typically 2mg or 5mg)
- Sterile work surface
How to Reconstitute Injectable
- 1Clean work area and hands thoroughly with alcohol
- 2Calculate required BAC water volume using calculator below
- 3Draw calculated BAC water slowly into syringe
- 4Inject BAC water slowly down the side of vial (never directly onto powder)
- 5Gently swirl vial until powder completely dissolves (never shake vigorously)
- 6Store reconstituted solution in refrigerator and use within 28 days
What to Expect Injectable
Week 1-2: Reduced inflammation and improved tissue sensation. Week 2-4: Accelerated healing rate and improved tissue quality. Week 4-8: Maximum tissue repair and regenerative benefits. Week 6-12: Continued improvement in tissue strength and function. Side effects: Generally minimal, possible injection site reactions. Most effective for: Muscle, tendon, ligament, and soft tissue injuries.
Side Effects & Safety
Use sterile injection technique to prevent infection. Mild injection site reactions are normal and temporary. Consult healthcare provider if on immunosuppressive medications. Not recommended during active cancer treatment. Avoid during pregnancy or breastfeeding. WADA prohibited - not for competitive athletes.
Use sterile injection technique to prevent infection. Mild injection site reactions are normal and temporary. Consult healthcare provider if on immunosuppressive medications. Not recommended during active cancer treatment. Avoid during pregnancy or breastfeeding. WADA prohibited - not for competitive athletes.
Community Insights
TB-500 should be stored at Fridge 2-6°C, use within 28 days.
Molecular Information
References
- Cardiac Tissue Regeneration (2016)
- Muscle Fiber Regeneration (2015)
- Corneal Healing Research (2014)
- Dermal Wound Healing Study (2012)
Research reference only. Not medical advice.