Cyclic Glycine-Proline

Cyclic glycine-proline (cGP) is a naturally occurring small cyclic dipeptide belonging to the 2,5-diketopiperazine family. It is endogenous to the human body, found in plasma, breast milk, and cerebrospinal fluid. cGP is a metabolite of insulin-like growth factor-1 (IGF-1) and plays a key role in regulating IGF-1 bioavailability by competing with IGF-1 for binding to IGFBP-3. Research suggests cGP has neuroprotective, nootropic, and cardioprotective properties, with clinical trials showing benefits for cognitive function, stroke recovery, and metabolic health.

• Cognitive Enhancement
• Neuroprotection
• Neurodegenerative Diseases

Neuroprotection, cognitive enhancement, IGF-1 optimization, cardiovascular support, metabolic health, convenient oral administration, crosses blood-brain barrier

cGP competes with IGF-1 for binding to IGFBP-3, thereby regulating the amount of bioavailable IGF-1 in circulation. It normalizes IGF-1 function - promoting activity when insufficient and inhibiting when excessive. Also acts as positive allosteric modulator of AMPA and GABA-A receptors and increases BDNF levels.

Research protocols from published literature — not dosing recommendations.

• IGF-1 — Synergistic: cGP is a metabolite of IGF-1 and regulates its bioavailability by competing for IGFBP-3 binding - normalizes IGF-1 function
• BPC-157 — Compatible: Different mechanisms - BPC-157 promotes tissue repair while cGP modulates IGF-1 function
• Semax — Compatible: Both have neuroprotective and nootropic effects through different pathways
• Selank — Compatible: Complementary cognitive enhancement - Selank for anxiety, cGP for IGF-1 optimization
• GH Secretagogues — Monitor Combination: Both affect growth hormone/IGF-1 axis - monitor for combined effects on IGF-1 levels

Week 1-2: Possible subtle improvements in mental clarity. Week 2-4: Enhanced cognitive function and focus may become noticeable. Week 4-8: Neuroprotective and metabolic benefits accumulating. Week 8-12: Optimal IGF-1 regulation and sustained cognitive support. Individual responses vary based on baseline cGP/IGF-1 ratio. Most effective for: Cognitive decline prevention, healthy aging, metabolic support.

cGP is endogenous to the human body - naturally found in plasma, breast milk, and CSF. Generally well-tolerated with excellent safety profile in clinical studies. No significant adverse events reported in available research. Start with lower dose to assess individual response. Consult healthcare provider if taking medications affecting IGF-1 or growth hormone. Limited long-term human data - most studies are short to medium term.

cGP is endogenous to the human body - naturally found in plasma, breast milk, and CSF. Generally well-tolerated with excellent safety profile in clinical studies. No significant adverse events reported in available research. Start with lower dose to assess individual response. Consult healthcare provider if taking medications affecting IGF-1 or growth hormone. Limited long-term human data - most studies are short to medium term.

Cyclic Glycine-Proline should be stored at Room temperature, cool dry place.