Kisspeptin

Kisspeptin is a family of neuropeptides encoded by the KISS1 gene that acts as a master regulator of the reproductive system. It potently stimulates gonadotropin-releasing hormone (GnRH) neurons, making it essential for puberty initiation, fertility, and reproductive function. Research explores its therapeutic potential for infertility, low libido, and reproductive disorders.

• Hypogonadotropic Hypogonadism
• IVF Ovulation Trigger
• Hypothalamic Amenorrhea

Potent stimulation of reproductive hormones (LH/FSH), restoration of natural testosterone production, fertility enhancement, and sexual function support. Suitable for addressing hypogonadism and reproductive disorders.

Kisspeptin binds to GPR54/KISS1R receptors on GnRH neurons in the hypothalamus, triggering pulsatile release of GnRH. This stimulates pituitary secretion of LH and FSH, which in turn promote gonadal steroid production and reproductive function.

Peak plasma concentration: 3 min. Elimination half-life: 28 min. Largely cleared by: ~2.3 hrs.

Research protocols from published literature — not dosing recommendations.

• GnRH — Synergistic: Kisspeptin stimulates GnRH release, working upstream in the reproductive axis
• hCG — Alternative: Kisspeptin may serve as safer alternative to hCG for IVF ovulation trigger
• Testosterone — Compatible: May help restore natural testosterone production through LH stimulation
• Estrogen — Compatible: Kisspeptin function is modulated by sex steroids in feedback loops

Supplies:

• Bacteriostatic water (BAC water) or sterile water
• Insulin syringes (0.5-1mL)
• Alcohol swabs
• Peptide vial
• Sterile work surface

1. 1Clean work area and hands thoroughly with alcohol
2. 2Calculate required BAC water volume using calculator below
3. 3Draw calculated BAC water into syringe
4. 4Inject slowly down vial side (not directly onto powder)
5. 5Gently swirl until completely dissolved (never shake)
6. 6Store reconstituted solution in refrigerator at 2-8°C
7. 7Use within 7 days for KP-10, up to 14 days for KP-54

Hours 2-5: LH surge peaks (3-5x baseline). Hours 12-14: LH returns to baseline. Day 1-2: Testosterone/estradiol increase in response to LH. Week 2-4: Potential improvements in sexual function and libido. Important: Do NOT use daily - causes receptor desensitization.

Use sterile injection technique to prevent infection. CRITICAL: Avoid daily administration - causes tachyphylaxis (desensitization). Recommended frequency: 2-3x per week maximum. May cause cardiovascular effects (vasoconstriction) - caution with heart disease. Not recommended during pregnancy or breastfeeding. Consult reproductive endocrinologist for fertility applications. Monitor for signs of ovarian hyperstimulation in women.

Use sterile injection technique to prevent infection. CRITICAL: Avoid daily administration - causes tachyphylaxis (desensitization). Recommended frequency: 2-3x per week maximum. May cause cardiovascular effects (vasoconstriction) - caution with heart disease. Not recommended during pregnancy or breastfeeding. Consult reproductive endocrinologist for fertility applications. Monitor for signs of ovarian hyperstimulation in women.

Kisspeptin should be stored at Fridge 2-8°C, use within 7-14 days.