Melanotan I

Melanotan I (afamelanotide) is a synthetic analog of α-melanocyte stimulating hormone that selectively targets MC1 receptors to stimulate melanin production. While an FDA-approved implant version (SCENESSE®) exists for rare medical conditions, research-grade injectable Melanotan I is studied for its photoprotective and tanning effects through regular subcutaneous administration.

• Enhanced Tanning Response
• Photoprotection
• Even Pigmentation

Research-grade injectable Melanotan I provides precise dosing control and rapid onset of tanning effects. Unlike the FDA-approved SCENESSE® implant, injectable form allows flexible dosing and can be administered at home. Produces visible tanning within 1-2 weeks with proper UV exposure.

Subcutaneous injection delivers Melanotan I directly into systemic circulation with 100% bioavailability. 30-minute half-life requires multiple daily injections for sustained MC1R activation and melanin production.

Research protocols from published literature — not dosing recommendations.

• Melanotan II — Compatible: Both target melanocortin receptors but Melanotan I has better safety profile and selectivity for MC1R. Should not be combined due to overlapping mechanisms and additive effects.
• UV Exposure — Synergistic: Melanotan I enhances tanning response to UV exposure, allowing deeper pigmentation with less sun exposure. Reduces required UV dose for tanning by approximately 50%.
• Beta-Carotene — Compatible: Natural carotenoid provides additional photoprotection. No known interactions with Melanotan I. Can be used together for enhanced skin protection.
• Tretinoin/Retinoids — Monitor Combination: Retinoids increase skin photosensitivity while Melanotan I provides photoprotection. Monitor for skin reactions and adjust UV exposure accordingly.
• Photosensitizing Medications — Use Caution: Antibiotics, diuretics, and other photosensitizing drugs may increase UV sensitivity. Enhanced monitoring recommended when combining with Melanotan I.
• Self-Tanning Products — Compatible: Topical self-tanners work through different mechanisms (DHA) and can be used alongside Melanotan I for enhanced cosmetic appearance.

Supplies:

• Bacteriostatic water (BAC water)
• Insulin syringes (29-31 gauge)
• Alcohol swabs
• Melanotan I lyophilized powder vial

1. 1Allow vial to reach room temperature (15-20 minutes)
2. 2Clean vial top with alcohol swab and allow to dry
3. 3Calculate required bacteriostatic water volume using the calculator below
4. 4Draw calculated volume of bacteriostatic water into syringe
5. 5Inject water slowly down the inside wall of the vial (never directly onto powder)
6. 6Gently swirl until powder completely dissolves (never shake)
7. 7Solution should be clear - discard if cloudy or contains particles
8. 8Store reconstituted solution in refrigerator at 2-8°C

Days 1-3: Possible mild nausea, facial flushing, reduced appetite. Days 3-7: Initial skin darkening, increased pigmentation of moles and freckles. Week 1-2: Noticeable tanning with minimal UV exposure, enhanced tanning response. Week 2-4: Peak tanning effects, maintained pigmentation with reduced injection frequency.

Research peptide - not approved for human consumption, sold for research purposes only. Start with lower doses to assess individual tolerance and response. Monitor moles and skin changes - perform regular self-examinations. Use proper sterile injection technique to prevent infections. Maintain UV protection despite enhanced tanning - still risk of overexposure.

Research peptide - not approved for human consumption, sold for research purposes only. Start with lower doses to assess individual tolerance and response. Monitor moles and skin changes - perform regular self-examinations. Use proper sterile injection technique to prevent infections. Maintain UV protection despite enhanced tanning - still risk of overexposure.

Melanotan I should be stored at Powder: room temperature or refrigerated; Reconstituted: 2-8°C for up to 4 weeks.