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Pinealon

Pinealon (Glu-Asp-Arg/EDR) is a synthetic tripeptide bioregulator developed in Russia that demonstrates unique DNA-interaction capabilities for neuroprotection and cognitive enhancement.

Also known as: Synthetic Tripeptide, Neuroprotection & Cognitive Enhancement

Typical Dose 5mg daily
Storage Refrigerate reconstituted; store lyophilized powder away from light
How Often Once daily

Overview

Pinealon (Glu-Asp-Arg/EDR) is a synthetic tripeptide bioregulator developed in Russia that demonstrates unique DNA-interaction capabilities for neuroprotection and cognitive enhancement. Research suggests benefits for traumatic brain injury recovery, age-related cognitive decline, and cellular aging processes through direct gene expression modulation.

Key Benefits

  • Traumatic Brain Injury Recovery
  • Cellular Neuroprotection
  • Stroke Recovery Support

Highest bioavailability, direct systemic delivery, established clinical protocols with proven efficacy

Mechanism of Action

Subcutaneous injection provides optimal bioavailability and systemic distribution for neuroprotection and DNA interaction

Research Protocols Injectable

GoalDoseFrequencyRoute
Neuroprotection5mg dailyOnce dailySubcutaneous
Cognitive Enhancement100-300μgDaily or every other daySubcutaneous
Anti-aging Protocol5mg daily20 days, 2-3x yearlySubcutaneous

Research protocols from published literature — not dosing recommendations.

Peptide Interactions

  • Epitalon — Synergistic: Enhanced neuroprotection and anti-aging effects through complementary telomerase activation and DNA interaction pathways. Russian protocols combine both for comprehensive longevity support.
  • Cortexin — Synergistic: Synergistic cognitive recovery in stroke patients through complementary brain region targeting. Pinealon provides DNA-level neuroprotection while Cortexin offers tissue-level support.
  • Thymalin — Compatible: Safe combination supporting neural-immune axis optimization. Long-term Russian protocols show 2.5-fold mortality reduction when combined with Epithalamin.
  • Melatonin — Monitor Combination: Monitor sleep patterns and melatonin sensitivity. Pinealon stimulates endogenous serotonin production, potentially allowing reduced exogenous melatonin doses.
  • BPC-157 — Compatible: Different mechanisms with no known interactions. BPC-157 focuses on tissue repair while Pinealon targets neurological and aging pathways.
  • NAD+ — Compatible: Complementary anti-aging mechanisms. NAD+ supports cellular energy while Pinealon provides DNA-level protection and gene expression modulation.

Peptide Instructions Injectable

Supplies:

  • Lyophilized Pinealon powder
  • Bacteriostatic water for injection
  • Insulin syringes (30-31 gauge)
  • Alcohol swabs
  • Sterile vials for mixing

How to Reconstitute Injectable

  1. 1Remove lyophilized powder and bacteriostatic water from refrigeration
  2. 2Clean vial tops with alcohol swabs and allow to dry
  3. 3Draw appropriate volume of bacteriostatic water into syringe
  4. 4Inject water slowly down the side of the peptide vial to avoid foam
  5. 5Gently swirl (do not shake) until powder dissolves completely
  6. 6Store reconstituted solution in refrigerator at 2-8°C
  7. 7Use within 30 days of reconstitution for optimal potency

What to Expect Injectable

Week 1-2: Improved mental clarity and focus. Week 2-3: Enhanced cognitive processing and memory. Week 3-4: Peak neuroprotective and anti-aging benefits. Side effects: Minimal injection site reactions. Most effective for: Cognitive enhancement, neuroprotection.

Side Effects & Safety

Use sterile injection technique. Rotate injection sites to prevent irritation. Store reconstituted peptide in refrigerator. Medical supervision recommended.

Use sterile injection technique. Rotate injection sites to prevent irritation. Store reconstituted peptide in refrigerator. Medical supervision recommended.

Community Insights

Pinealon should be stored at Refrigerate at 2-8°C, use within 30 days.

Molecular Information

Molecular Weight 418.4 Da
Length 3
Type Tripeptide
Sequence Glu-Asp-Arg (EDR)

References

  1. Molecular mechanisms of peptide bioregulation in aging Khavinson, V.K., Linkova, N.S., Tarnovskaya, S.I. · Russian Journal of Bioregulation and Gerontology 2022
  2. Multi-peptide geroprotective protocols: Long-term clinical outcomes Popovich, I.G., Voitenkov, B.O., Anisimov, V.N. · Aging and Disease 2022
  3. Peptides and aging: Bioregulation of genome activity Khavinson, V.K., Tarnovskaya, S.I., Linkova, N.S. · Molecules 2021
  4. Peptides EDR and KED prevent dendritic spine elimination in 5xFAD mice Linkova, N.S., Drobintseva, A.O., Orlova, O.A., Khavinson, V.K. · Pharmaceuticals 2021
  5. 5xFAD Alzheimer's Mouse Model · 2021
  6. Dose-dependent effects of peptide bioregulators on spatial learning in diabetic rats Karantysh, G.V., Evstigneeva, R.P., Petukhov, A.E. · Neurochemical Journal 2020
  7. Diabetic Rat Model - Spatial Learning · 2020
  8. Neuroprotective effects of synthetic peptides in cellular models of neurodegeneration Tarnovskaya, S.I., Linkova, N.S., Khavinson, V.K. · Neuropeptides 2019
  9. Antioxidant System Modulation · 2019
  10. Circadian rhythm regulation by peptide bioregulators in sleep disorders Kuznik, B.I., Davydov, S.O., Erokhina, I.L. · Sleep Medicine Reviews 2018
  11. Insomnia Clinical Protocol · 2018
  12. Peptide bioregulators and aging: Results of clinical studies Anisimov, V.N., Khavinson, V.K., Morozov, V.G. · Clinical Gerontology 2015
  13. Human Clinical Trial - Post-Traumatic Cerebrasthenia · 2015
  14. Aging Study - Polymorbidity Patients · 2015

Research reference only. Not medical advice.