Pinealon
Pinealon (Glu-Asp-Arg/EDR) is a synthetic tripeptide bioregulator developed in Russia that demonstrates unique DNA-interaction capabilities for neuroprotection and cognitive enhancement.
Also known as: Synthetic Tripeptide, Neuroprotection & Cognitive Enhancement
Overview
Pinealon (Glu-Asp-Arg/EDR) is a synthetic tripeptide bioregulator developed in Russia that demonstrates unique DNA-interaction capabilities for neuroprotection and cognitive enhancement. Research suggests benefits for traumatic brain injury recovery, age-related cognitive decline, and cellular aging processes through direct gene expression modulation.
Key Benefits
- Traumatic Brain Injury Recovery
- Cellular Neuroprotection
- Stroke Recovery Support
Highest bioavailability, direct systemic delivery, established clinical protocols with proven efficacy
Mechanism of Action
Subcutaneous injection provides optimal bioavailability and systemic distribution for neuroprotection and DNA interaction
Research Protocols Injectable
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Neuroprotection | 5mg daily | Once daily | Subcutaneous |
| Cognitive Enhancement | 100-300μg | Daily or every other day | Subcutaneous |
| Anti-aging Protocol | 5mg daily | 20 days, 2-3x yearly | Subcutaneous |
Research protocols from published literature — not dosing recommendations.
Peptide Interactions
- Epitalon — Synergistic: Enhanced neuroprotection and anti-aging effects through complementary telomerase activation and DNA interaction pathways. Russian protocols combine both for comprehensive longevity support.
- Cortexin — Synergistic: Synergistic cognitive recovery in stroke patients through complementary brain region targeting. Pinealon provides DNA-level neuroprotection while Cortexin offers tissue-level support.
- Thymalin — Compatible: Safe combination supporting neural-immune axis optimization. Long-term Russian protocols show 2.5-fold mortality reduction when combined with Epithalamin.
- Melatonin — Monitor Combination: Monitor sleep patterns and melatonin sensitivity. Pinealon stimulates endogenous serotonin production, potentially allowing reduced exogenous melatonin doses.
- BPC-157 — Compatible: Different mechanisms with no known interactions. BPC-157 focuses on tissue repair while Pinealon targets neurological and aging pathways.
- NAD+ — Compatible: Complementary anti-aging mechanisms. NAD+ supports cellular energy while Pinealon provides DNA-level protection and gene expression modulation.
Peptide Instructions Injectable
Supplies:
- Lyophilized Pinealon powder
- Bacteriostatic water for injection
- Insulin syringes (30-31 gauge)
- Alcohol swabs
- Sterile vials for mixing
How to Reconstitute Injectable
- 1Remove lyophilized powder and bacteriostatic water from refrigeration
- 2Clean vial tops with alcohol swabs and allow to dry
- 3Draw appropriate volume of bacteriostatic water into syringe
- 4Inject water slowly down the side of the peptide vial to avoid foam
- 5Gently swirl (do not shake) until powder dissolves completely
- 6Store reconstituted solution in refrigerator at 2-8°C
- 7Use within 30 days of reconstitution for optimal potency
What to Expect Injectable
Week 1-2: Improved mental clarity and focus. Week 2-3: Enhanced cognitive processing and memory. Week 3-4: Peak neuroprotective and anti-aging benefits. Side effects: Minimal injection site reactions. Most effective for: Cognitive enhancement, neuroprotection.
Side Effects & Safety
Use sterile injection technique. Rotate injection sites to prevent irritation. Store reconstituted peptide in refrigerator. Medical supervision recommended.
Use sterile injection technique. Rotate injection sites to prevent irritation. Store reconstituted peptide in refrigerator. Medical supervision recommended.
Community Insights
Pinealon should be stored at Refrigerate at 2-8°C, use within 30 days.
Molecular Information
References
- Molecular mechanisms of peptide bioregulation in aging
- Multi-peptide geroprotective protocols: Long-term clinical outcomes
- Peptides and aging: Bioregulation of genome activity
- Peptides EDR and KED prevent dendritic spine elimination in 5xFAD mice
- 5xFAD Alzheimer's Mouse Model
- Dose-dependent effects of peptide bioregulators on spatial learning in diabetic rats
- Diabetic Rat Model - Spatial Learning
- Neuroprotective effects of synthetic peptides in cellular models of neurodegeneration
- Antioxidant System Modulation
- Circadian rhythm regulation by peptide bioregulators in sleep disorders
- Insomnia Clinical Protocol
- Peptide bioregulators and aging: Results of clinical studies
- Human Clinical Trial - Post-Traumatic Cerebrasthenia
- Aging Study - Polymorbidity Patients
Research reference only. Not medical advice.