SS-31 (Elamipretide)

SS-31, also known as Elamipretide or Bendavia, is a small aromatic-cationic tetrapeptide that selectively targets mitochondria. Unlike traditional antioxidants, SS-31 specifically binds to cardiolipin in the inner mitochondrial membrane, protecting it from oxidative damage and improving cellular energy production. This unique mechanism makes it particularly promising for age-related conditions, heart disease, and mitochondrial disorders.

• Enhanced ATP Production
• Oxidative Stress Reduction
• Mitochondrial Disease Support

Directly protects mitochondria, improves cellular energy, reduces oxidative damage, enhances exercise capacity

Selectively binds to cardiolipin in inner mitochondrial membrane, preventing lipid peroxidation and optimizing electron transport chain function

Peak plasma concentration: 30 min. Elimination half-life: 4 hrs. Largely cleared by: ~20 hrs.

Research protocols from published literature — not dosing recommendations.

• NAD+ — Synergistic: Both support mitochondrial function through different mechanisms - SS-31 protects membranes while NAD+ enhances energy production
• MOTS-c — Synergistic: Both are mitochondrial peptides - MOTS-c regulates metabolism while SS-31 protects mitochondrial structure
• Humanin — Synergistic: Another mitochondrial-derived peptide - may work together to protect cellular function and reduce apoptosis
• GHK-Cu — Compatible: Different mechanisms - GHK-Cu works on gene expression while SS-31 directly protects mitochondria
• BPC-157 — Compatible: No known interactions - BPC-157 focuses on tissue repair while SS-31 targets cellular energetics
• Thymosin Beta-4 — Compatible: Both have cardioprotective effects through different pathways - may be complementary

Supplies:

• SS-31 (Elamipretide) peptide vial
• Bacteriostatic water or saline
• Insulin syringes (for SubQ)
• Alcohol prep pads
• Sterile filter (optional for IV use)

1. 1Clean vial top with alcohol pad
2. 2Add appropriate amount of bacteriostatic water (typically 1-2mL per 10mg)
3. 3Gently swirl to dissolve - SS-31 dissolves readily
4. 4Solution should be clear and colorless
5. 5For IV use, may require sterile filtration
6. 6Label with concentration and date
7. 7Store in refrigerator immediately

Day 1-3: Subtle energy improvements, reduced fatigue. Week 1-2: Better exercise endurance, faster recovery. Week 2-4: Improved stamina, clearer thinking, better sleep quality. Week 4-8: Significant improvements in exercise capacity. Week 8-12: Sustained energy improvements, potential biomarker changes.

Excellent safety profile in clinical trials. No significant side effects reported at therapeutic doses. May cause mild injection site reactions. Monitor for allergic reactions (very rare). Safe for long-term use based on current data. No known drug interactions.

Excellent safety profile in clinical trials. No significant side effects reported at therapeutic doses. May cause mild injection site reactions. Monitor for allergic reactions (very rare). Safe for long-term use based on current data. No known drug interactions.

SS-31 (Elamipretide) should be stored at Refrigerate after reconstitution, protect from light, use within 30 days.